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.25 ACP vs .22LR: Which is Better for CCW?

For some folks, the .22 might be the best option. You can buy ammo about anywhere, it is not super expensive, recoil is not a big issue and guns in .22 caliber are plentiful. Based on forum posts, I think most people here can afford more expensive guns and ammo, but not everyone is as fortunate.
 
Tale of the tape (as they say):

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.25 should be more reliable ammunition wise (rimfire priming issues on the .22). That said the .22 ammo is a lot more plentiful, cheaper. I wouldn’t want to be on the wrong end of either. That said, not much energy there. You’d best be able to shoot it well.
 
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