I've run the gauntlet of wilderness handguns, suffering serious financial wounds. I've sold a 6" Model 29. It was huge, far too heavy, inconvenient to carry, slow to battery, and don't let anyone tell you that they can rapid fire a .44 Mag with accuracy. Due to excessive recoil, I called it a one-and-done handgun. I would have been lucky to get off one aimed round at a charging bear.
A 4" .357 Mag loaded with 180 grain hard cast rounds is a darn good choice.
The insurmountable problem with revolvers is reloading them.
After using more than a few handguns, I've come to the conclusion that the Springfield Armory TRP .45 ACP is the best for me wilderness handgun. I'd much rather fire 9 fast and accurate 230 grain Fed HST LE +P rounds at a charging mean critter that pray that I could get off one aimed .44 Mag round. The unequaled benefit of semis is they can be reloaded within seconds and without having to lose vision of a dangerous beast.
The 10MM would be an excellent choice.
The .45 ACP at standard pressure is a powerful round.
Months ago, in a wilderness handgun conversation with a friend, the .45 Super was introduced into the mix. Working off Buffalo Bore's ballistics tables alone, a 255 grain hard cast .45 Super round appeared to be an extremely powerful cartridge. The conversation progressed to theory. Would the 10MM survive if 1911-A1 manufacturers marketed iterations of 1911-A1s factory chambered for the .45 Super? Theory always invites conjecture. Then there's the reality rub: would the .45 Super demonstrate a marked increase of efficacy in actual use against mean critters that aim to dine on fishermen? Lacking proof, it's dandified theory.
There is no doubt in my mind that my Springfield Armory TRP .45 ACP is more reliable than any revolver. But that's merely my opinion born of experience.