My one and only EDC is my XDs 9mm with Viridian laser, and Alien Gear IWB holster. Day in, day out, I don't notice it unless I go out for some reason without it.
Today, I got home from work. Put on cycle shorts, cargo shorts with a tac belt over them, my IWB holster, and a tank top. Did 6 miles on my mountain bike for a cardio workout (6 miles, 26 minutes, 800' elevation change up and down throughout), without even caring it was there, ready to go if I needed it. No poking, no rubbing, no interference with any motions.
I second the idea that you need "A" carry weapon. Period. You can have other toys for the range, other weapons for home defense, but for wear and carry? Get one. Learn it. Practice it. Know it well enough that you don't have to think about it. Because if it comes down, and you need it to survive...thinking takes time, and time is your enemy. Let your muscles do the work, and get out alive.