If they are obviously armored—yes.
The most common type of armor you’ll likely see is a plate carrier (because it’s cheap and effective) with III or better.
I don’t care what you’re carrying, if it’s a handgun, it won’t punch through it. You’re gonna have to hit where it ain’t.
The armpit is also a solid shot, if presented…if you have a properly performing round in your handgun, you should also be able to punch through the bi/tricep and humerus into the chest.
There’s the pelvis, but…it’s a low percentage stopper with most handguns.