Absolutely.
First off, you greatly increase the chance of an unintended discharge when manipulating the hammer, both in decocking it (should the thumb slip off the spur, allowing it to fall completely) or, in the drawstroke (same)...as well as taking the chance that the half-**** notch will hold on the hammer, particularly if dropped on it...or if it simply slips off on it’s own with enough force to detonate the primer.
Whereas, in condition 1, all you do is safe the pistol, and you are good to go.
I acknowledge that some people will carry their 1911 condition zero (usually achieved by by taking it off safe after holstering)...and I’d still consider that safer, with the caveat that it requires a proper holster in good condition.