IMO, depending on the carry load, the firearm and the conditions, I would say yes, it’s on the cusp of being too much gun for humanoid defense. A woods gun, or home defense where collateral damage should be minimal or nonexistent, cool, but magnum loads, and those I consider to be (+p+) loads like the full house 10mm, can have some pretty devastating results. For home defense or go to war, then hell yes, load up for predator disposals, but for concealed carry, I’ll pass; too much gun for the average day to day and possible encounter. Should I be faced with having to pull my gun and use a round of .45ACP or even 9mm and doesn’t stop the threat, I’ll send another until it does. Knowing that the FBI test of 12” is only if the subject is turned sideways, or if the round needs to pass through the arm and possibly bone, and most any duty round of today will do that; why take the risk of deep over penetration and the possible serious after effects. Chances are high, you might not have a clear background when you need to defend yourself or a loved one.