I trained with and carried a .45 ACP 1911 or SIG P220 loaded with 230 Hydra-Shok for almost 30 years, I love my .45 ! After a bad wreck, hit by a drunk in a pickup truck on my Harley and was forced to re-evaluate as I could no longer safely put my .45 on target & repeat for 2nd shot. Went down to the .40 which I found a little snappier, but still could not safely & accurately put 2nd shot where it should be. Finally picked up a couple of EMP’s in 9mm with both 3” & 4” CCC, and found it much easier to do what I always did. With the HST load in a 3” barrel I got the same size if not larger wound size as I did with my 3.3” SIG in .45ACP.
I love to shoot my 3” EMP .40 & .357 Sig P229 4” on a regular basis now that I’m getting the feeling and strength back on my right side. My advice is research your gun and it’s capability, then find the appropriate ammunition for “YOUR” pistol. I’ll take my .45 ACP IN A 4” barrel all day long because that’s what I’ve done for a long time and I’m most accurate with, but if I’m having a bad day my 3” EMP 9mm loaded with 147 HST feels just fine and because the HST was specifically designed for 3” barrel in CC or CQB situations, you get full expansion every time. When you take into account 85+% of self defense shootings take place under 10 yards (then become a homicide committed by you) I can’t say the same for my .45 yet!
At home I keep my stainless elite P226 in .357 SIG with optics & laser / flasher and a 13 round semi auto shotgun full of 00 & Hydra-Shok slugs at the ready, and sadly have had to use this combination effectively, all caught on video. 4 against me, they didn’t stand a chance in my house... No charges filed.