Honestly, this post went downrange from what I was thinking in my head in the OP... it was my first post, sorry. So I am a multi vet and hunter, of course I know a .22 can kill most anything. That was not really what I had in mind when I made an obviously poor choice in titles. I know there are folks here who do carry various .22 revolvers and such, pocket carries, and I assume that having trained with them, they will do the job if needed. Personally I usually carry a 9 or 10, and were I to carry a revolver for some reason, it would probably be my Bulldog Pug 44 Special.
I think, if I remember right, what I was thinking to myself was if I had a safe full of options for CCW, why would I ever choose a .22 over any of the other things... OR, say I am talking to a new guy, about buying his first gun, that would be used for home defense and CCW, would I think to talk .22s to him, or would I go right for a 9/38/45 etc for whatever reason.
So while I have various .22's and we all acknowledge that in the right circumstance they will do the thing, if sitting next to a safe full of all the other options we all have, would picking up the .22 actually be plausible (: superficially fair, reasonable) vs the options? For me the answer is no, the .22s are behind the 9s in the pistol safe.