I carried a .45 for thirty plus years. I love the .45. However, 9, 40, 45, etc. are all the same. I've seen the ER pics comparing wound channels. There is no discernable difference between them. Pistol calibers are a defensive tool. .357 was the supposed holy grail of one shot stopability, but it's all a myth. I watched the video of a perp shoot a clerk pointblank in the chest with a .357 and she stood there arguing with him for another couple of minutes before eventually going to her knees and bleeding out. Stopability is a term we love to throw around, but it's all horse pucky. Pistols are merely defensive weapons. If you want to put down a threat, shoot them with a carbine in a rifle caliber.