I just want to give a last couple of thoughts on this. I know I'm not going to change most of your minds. But, hopefully, a few people will read this and give these things some thought based on the merits.
I am no expert. I'm not a shooting instructor. No LE or military experience. Just a regular schmoe that has been shooting a long time, shot a few pistol matches, had a little bit of formal training, and daily carried for years. If what I have to say makes sense to you, then my experience and background don't matter. If it does not make sense to you, then my experience and background don't matter.
1) A number of posts here are based on LE or military experience. That is really (seriously!) appreciated and fine, as far as it goes. But, at least in my mind, this question being discussed is one for people who are not LE or military. LE and military have their training and protocols and this forum thread is irrelevant to them. It's for the rest of us.
2) What LE and military do is not necessarily the same as what is best for regular schmoes. There are several reasons for that. One, their job is to go into bad situations. For the rest of us, that is not the case. Two, they have a raft of concerns about liability that the rest of us don't. I think that is true for professionals vs non-professionals in every industry. I teach scuba diving. As a scuba professional, the things I do and my concerns about liability are just not the same as a non-pro.
So, just as one example, because some LE agency somewhere decides that all duty guns need to have a manual safety that does NOT necessarily mean that it is a Best Practice for regular schmoes to have a manual safety. Similarly, if an agency says NO duty guns can have manual safeties, it does not mean that is a Best Practice for regular schmoes, either. The point is not which is best. The point is that what a LE agency does is NOT necessarily the example of Best Practice for a regular schmoe, regardless of what they do. They have different criteria than the rest of us have.
I'll go out on a limb and say that there is NO Law Enforcement agency in the U.S. where the training and tactics that they use have not been reviewed and approved by the agency's General Counsel, who has made sure the agency is protected against liability to the maximum extent possible. So, no LE trainer can say with full honesty that their agency's training absolutely teaches what is THE BEST possible practice. Anything they teach COULD be different in some way from what would be best, in order to protect the agency's liability. I'm sure someone will want to argue this, but until someone says "our GC said we can't have this in our training, but we do it anyway", I will be skeptical.
Regardless, the only point here is what I started with: What LE and military do is not NECESSARILY Best Practice for us schmoes.
3) Using LE and military training and tactics as models for regular schmoes also implies a presumption that I think is faulty. See point #1. They usually know well in advance when they are going into a potentially bad situation. That is their job. Us regular schmoes don't have the same operating parameters. We will almost never know when something bad is about to happen. If you are not military or LE and you know that you need to "be ready" you should have already been turning around and going the other way. LE has a job to go into the "bad parts of town." I don't have that job, so I don't do that. Posts have talked about "avoiding the situation in the first place" and I think that is key. If your spidey sense tingles, you exit before the situation develops. And THAT means that, if you ever do need to draw your weapon, it is VASTLY more likely to be the result of a surprise, versus what happens to LE or military.
4) The notion that if you train well enough and in sufficient amounts, you can "train out" the concern about manual safeties is one that is rendered completely obsolete (and wrong) by the modern study of Human Factors. Thanks to modern science, we know for a fact that humans are *gasp* going to make mistakes. And the more steps you have in a process, the more likely it is that the process will not be successful. I think it is simply indisputable that, with all other factors being equal, a process of draw, achieve correct grip, sweep off thumb safety, aim, press trigger, WILL have more failures than a process of draw, aim, press trigger. ESPECIALLY when the circumstances are that the shooter is suddenly, by virtue of surprise, in fear of imminent danger from a threat in very close proximity. And that is true no matter how well and much you train. Your training will improve performance, but it can never guarantee a 100% success rate.
I specifically mention very close proximity because we're not talking about LE or military. If the threat is not close, why are you going to guns instead of getting away? Yes, I know there are examples you can come up with where flight is not the correct option. I'm just making the point that MOST of the time, if you have no other choice but to go to guns, it seems very likely that the threat is going to be very close to you. Statistics for self-defense shootings (LE/military and other) all seem to support that.
5) From training I have had and reading I have done, the vast majority of self-defense shootings (for non-LE/military) are at such distances (i.e. close) that the time it takes to present the weapon and shoot is VASTLY more important that how accurate the gun is or what kind of sights it has. MOST of the time, the shooter wouldn't (or shouldn't) even take the time to achieve a sight picture. When the attacker is 5 feet away and coming at you, shooting from the hip before the attacker gets a hand on you is possible. The extra 1/2 a second (if you are GOOD) to get the gun up and get any kind of sight picture is the time where you lose the fight.
So, if you're carrying for self-defense, does it not make sense to set yourself up for the MOST LIKELY means of success? I.e. you are forced to guns, by a very close proximity threat, that has surprised you. The MOST likely process for success in that situation (as predicted by Human Factors) is to have the least number of steps in your process to defend yourself. Training hard and often will allow you to be successful with a 1911 a very high percentage of the time. But, training equally hard and often with a pistol with no safety other than a trigger dingus (but of equal quality) will allow you to be successful a slightly higher percentage of the time.
Or so it seems to me.
Note: My EDC is a 1911 and has been for about 30 years. *I* am so much more practiced with a 1911 than anything else, that I think my current choice of EDC is the most likely thing for ME to be successful with. But, that doesn't mean I can't read and understand the sense and the science of the situation. I can understand that if I put in the time to become as proficient with a Glock-STYLE pistol as I am with a 1911, I would be better off to change my EDC to that. But, I never owned a striker-fired pistol of any type until just last year. Always and only 1911/2011 guns (revolvers and 22LR stuff aside).